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Literature summary for 3.1.1.79 extracted from

  • Eichmann, T.O.; Kumari, M.; Haas, J.T.; Farese, R.V.; Zimmermann, R.; Lass, A.; Zechner, R.
    Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases (2012), J. Biol. Chem., 287, 41446-41457.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.1.79

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of His-tagged enzyme Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
76-0079 a commercial small molecule inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diacylglycerol + H2O Mus musculus
-
 monoacylglycerol + a carboxylate
-
 ?
additional information Mus musculus sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol ?
-
 ?
triacylglycerol + H2O Mus musculus
-
 diacylglycerol + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylglycerol + H2O
-
 Mus musculus monoacylglycerol + a carboxylate
-
 ?
additional information sn-1,3-diacylglycerol is the preferred substrate for the consecutive hydrolysis by hormone-sensitive lipase, the enzyme is less active with sn-1,2-diacylglycerol Mus musculus ?
-
 ?
triacylglycerol + H2O
-
 Mus musculus diacylglycerol + a carboxylate
-
 ?

Synonyms

Synonyms Comment Organism
HSL
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice accumulate sn-1,3-diacylglycerol and sn-2,3-diacylglycerol in white adipose tissue Mus musculus
physiological function the enzyme is crucial for the hydrolysis of diacylglycerol within the lipolytic cascade Mus musculus